Document Type
Article
Department
Neuroscience
Publication Date
5-2013
Abstract
In rodents, insufficient adenosine produces behavioral and physiological symptoms consistent with several comorbidities of autism. In rodents and humans, stimuli postulated to increase adenosine can ameliorate these comorbidities. Because adenosine is a broad homeostatic regulator of cell function and nervous system activity, increasing adenosine's influence might be a new therapeutic target for autism with multiple beneficial effects.
Comments
Authors' post-print. Final published version available at
http://www.sciencedirect.com/science/article/pii/S0028390812004492
Susan A. Masino, Masahito Kawamura, Jr. Jessica L. Cote, Rebecca B. Williams, David N. Ruskin. “Adenosine and Autism: A Spectrum of Opportunities.” Neuropharmacology 68 (May 2013): 116-21.