Title

Social stimuli increase activity of adult-born cells in the telencephalon of zebrafish (Danio rerio)

Document Type

Article

Department

​​Biology

Publication Date

8-1-2021

Abstract

Fish have particularly high levels of adult neurogenesis, and this high neurogenic capacity may contribute to behavioural plasticity. While it is known that adult-born cells can differentiate into neurons and incorporate into neural circuits, it is unclear whether they are responsive to external stimuli and are thereby capable of contributing to behavioural change. We tested whether cells born in the telencephalon of adult zebrafish are activated by social stimuli. We marked cell birth with BrdU and, 40 days later, exposed fish to brief (15 min) visual social stimuli and assayed cellular activity through immunolocalization of phospho-S6-ribosomal protein (pS6). BrdU+/pS6+ co-labelled cells were found in six brain regions, and, in four regions [dorsal (D), dorsomedial (Dm) and dorsolateral (Dl) zones of the dorsal telencephalon and pre-optic area (POA)], the number of co-labelled cells and fraction of BrdU+ cells that labelled positive for pS6 increased during social stimulation. These results are consistent with the hypothesis that adult-born neurons play a role in regulating social behaviour.

Comments

Article originally published in Journal of Experimental Biology under Open Access terms.

Publication Title

Journal of Experimental Biology

Volume

224

Issue

16

ISSN

00220949

DOI

10.1242/jeb.242253

PubMed ID

34405880

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