Triarylmethyl Cation Catalysis: A Tunable Lewis Acid Organocatalyst for the Synthesis of Bisindolylmethanes
Triarylmethyl cations serve as tunable organocatalysts for the synthesis of bisindolylmethanes. The catalyst structure can be modified to increase or decrease reactivity as needed to match the requirements of the substrate. High yields are achieved for a variety of substrates by using these green catalysts. Catalyst tuning allows for the use of less reactive electrophiles by increasing the reactivity of the catalyst. Acid-sensitive products can be isolated under these mild reaction conditions.
First 10 authors published as students at Trinity College, Hartford Connecticut. Article published under Open Access terms as:
Nicholas G. Boekell ’17, Dana J. Cerone ’18, Maria M. Boucher ’20, Phong K. Quach ’17, Wilfried B. Nganyak Tentchou ’21, Christine G. Reavis ’15, Ifeanyi I. Okoh ’15, Jordan O. A. Reid ’17, Hayley E. Berg ’15, Briana A. Chang ’16, Cheyenne S. Brindle. “Triarylmethyl Cation Catalysis: A Tunable Lewis Acid Organocatalyst for the Synthesis of Bisindolylmethanes.” SynOpen 1, no. 1 (2017): 97.